EFFECT OF THE MEGLUMINE ANTIMONIATE DURING FETAL PERIOD ON PHYSICAL DEVELOPMENT OF PUPS IN MICE

Abstract

The exposition to the quimical agents during the pregnant can alter the animal development and the maturation of the physiological systems. The Meglumine antimoniate (MA) is the first-choice of treatment of of leishmaniosis same presented toxicity and suppond neural impregnation. The aim this work was verify the physical developmental of the pups of Swiss mice exposed to MA during the fetal period. Pregnant dams received MA (100mg/kg/day) during day 13° to 18° of gestation – ddg. Control group received deionized water. At birth day (0 postnatal – dpn) the number and corporal weight of the pups of each litter was registered. The corporal weight of the pups was realized on day 3°, 5°, 7°, 14° and 21° postnatal. Physical development was assessed by monitoring daily on the 0 to 31º dpn the following parameters in 16 litters: birt of pilus, eye opening, ear unfolding, incisor eruption, vagina opening and descent of the testis. No statistic difference was observed in the number and corporal weight between the experimental and control pups at 0 dpn. The ponderal development of the pups of both the groups was similar, as well the appearance of indicators of the physical development. The maternal exposition in mice to MA throughout the fetal period did not interfere in the physical development of the pups.