[ID 54845] RESISTÊNCIA ANTIMICROBIANA: ASPECTOS CLÍNICOS E ECONÔMICOS NOS CUSTOS DA HOSPITALIZAÇÃO

ANTIMICROBIAL RESISTANCE: CLINICAL AND ECONOMIC ASPECTS OF HOSPITALIZATION COSTS

Abstract

Objective: To evaluate the clinical and economic aspects of antimicrobial resistance in blood culture in the direct costs of hospitalized patients. Methodology: Retrospective cross-sectional study carried out at a tertiary hospital in southern Brazil. The sample consisted of patients with positive blood culture, aged ≥14 years, hospitalized for a period ≥48 hours between January and December 2017. Microorganisms resistant to oxacillin, vancomycin, carbapenemics, cephalosporins, fluorquinolones and aminoglycosides were considered resistant. The direct costs of hospitalization were provided by the institution’s financial department. Data were analyzed using SPSS® version 20 software. Result: The study sample consisted of 261 patients, of these 62.45% presented resistant microorganism in the blood culture. Antimicrobial resistance was more frequent in intensive care unit patients (p=0.0017) with hospitalization in this unit for more than 15 days (p<0.001). Resistant microorganism blood culture increased the odds of mortality twice as compared to patients with sensitive microorganism blood culture (p=0.0016). The direct costs attributed to hospitalization were higher in patients with resistant microorganism blood culture compared to sensitive microorganism (p<0.001). Conclusion: Antimicrobial resistance in blood cultures was associated with prolonged intensive care unit hospitalization, mortality, and increased direct hospitalization costs.