Effects of octyl-metoxycinnamate (OMC) in the histopathology of testicle, kidney and liver in Wistar rats

OCTYL METHOXYCINNAMATE ON THE HISTOPATHOLOGY OF TESTICLE, KIDNEY AND LIVER IN WISTAR RATS

Abstract

Objective: To investigate the adverse effects that octyl-metoxycinnamate (OMC) can cause in reproductive, liverwort and renal functions, through the comparative analysis of the morphology of the testicles, kidneys and livers, sperm quality and changes in the body mass of Wistar rats. Methodology: The animals, with 2 months of age, were divided in two groups, which the first one, control, ingested only corn oil, from a initial dose of 0,6ml, and the second one, treated, ingested only the OMC, with the same initial dose. The doses were adjusted daily based on the current weight of the animal, in a proportion of 5ml/kg. After 21 days of exposition to the substances, the animals were sacrified and the laparotomy was made for the collect of testicles, kidneys and livers for histopathological analysis, beyond sperm samples for elaboration of the spermogram. Results: The histopathological analysis evidenced hemorrhagic áreas in the renal cortex parenchyma, cellular alterations and less preservated areas in the hepatocyte strands of the livers, and in the testicles there was a loss of seminiferous tubes and alterations in the cells of spermatogenic lineage. The spermogram analysis comproved that the substance caused an increase in the abnormal spermatozoides index, with and increase in the rate of anomalies in the head and tail. Conclusion: Was comproved that the analyzed solar filter, from morphological alterations in the organs and sperm quality, in fact affected the reproductive, liverwort and renal functions in the analyzed animals.