Tissue perfusion and functional capacity in individuals with peripheral arterial disease - a cross-sectional study
UM ESTUDO TRANSVERSAL
Keywords:
Peripheral Arterial Disease, Spectroscopy, Near-Infrared, Perfusion, ISWTAbstract
Objective: To compare resting tissue perfusion and functional capacity between healthy and individuals with Peripheral Arterial Disease (PAD); to evaluate the association between resting tissue perfusion after ischemic maneuver and functional capacity in the studied sample. Methodology: Exploratory, cross-sectional observational study consisting of two groups, diagnosed with PAD and healthy. Body mass index (BMI) and resting ankle-brachial index (ABI) were evaluated. The Near-Infrared Spectroscopy associated with arterial occlusion maneuver was used to measure tissue perfusion variables: baseline peripheral oxygen saturation (StO2), the value of the StO2 difference between the beginning and end of the maneuver, and the value of lower StO2 during the maneuver. The Incremental Shuttle Walk Test was applied to measure the functional capacity through the distance covered in the test. Results: 40 participants with PAD aged 64.28±10.50 years, 28 men and 12 women, BMI of 27.2±4.6 kg/m², right ABI 0.62±0.17, left ABI 0.61±0 .17, 15 had diabetes mellitus (37.5%); 40 healthy participants aged 64.23±10.38 years, 28 men and 12 women, BMI of 26.9±3.4 kg/m². Comparison between groups for tissue perfusion and functional capacity variables were significantly different; and the analysis of the correlation between tissue perfusion and functional capacity was found to be significant only for the group of healthy individuals. Conclusion: The worst tissue perfusion in individuals with PAD is not associated with functional capacity, therefore, it is possible to infer that other adaptive peripheral parameters are associated with functional capacity in these individuals.
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References
Monteiro DP, Ribeiro-Samora GA, Britto RR, Pereira DAG. Effects of modified aerobic training on muscle metabolism in individuals with peripheral arterial disease: a randomized clinical trial. Scientific Reports, 2019, v. 9, n. 1. Springer Science and Business Media LLC.
Presti C, Jr FM, Casella IB, Luccia N, Covre MR. Doença arterial periférica obstrutiva de membros inferiores: diagnóstico e tratamento. Projeto Diretrizes SBACV, 2015.
Frank U, Nikol S, Belch J, Boc V, Brodmann M, Carpentier PH, et al. Guideline on peripheral arterial disease of European Society For Vascular Medicine, 2019, volume 48/supplement 102.
Cunha-Filho IT, Pereira DAG, Carvalho, AMB, Campedeli L, Soares M, Freitas JS. The Reliability of Walking Tests in People with Claudication. American Journal Of Physical Medicine & Rehabilitation, 2007, v. 86, n. 7, p. 574-582. Ovid Technologies (Wolters Kluwer Health).
Monteiro DP, Britto RR, Carvalho MLV, Montemezzo D, Parreira VF, Pereira DAG. Shuttle walking test como instrumento de avaliação da capacidade funcional: uma revisão da literatura. Ciência & Saúde. 2014; 7(2):92-7.
Cunha-Filho IT, Pereira DAG, Carvalho AMB, Garcia JP, Mortimer LM, Burni IC. Correlação entre o índice tornozelo-braço antes e após teste de deslocamento bidirecional progressivo. Jornal Vascular Brasileiro. 2007, v. 6, n. 4, p. 332-338. FapUNIFESP (SciELO).
Coughlin PA, Kent PJ, Turton EP, Byrne P, Berridge DC, Scott DJ, et al. A New Device for the Measurement of Disease Severity in Patients with Intermittent Claudication. European Journal Of Vascular And Endovascular Surgery, 2001, v. 22, n. 6, p. 516-522. Elsevier BV.
Van Beekvelt MC, Colier WN, Wevers RA, Van Engelen BG. Performance of near-infrared spectroscopy in measuring local O 2 consumption and blood flow in skeletal muscle. Journal of Applied Physiology, 2001, v. 90, n. 2, p. 511-519.
Comerota AJ, Throm RC, Kelly P, Jaff M. Tissue (muscle) oxygen saturation (StO2): a new measure of symptomatic lower-extremity arterial disease. Journal Of Vascular Surgery, 2003, v. 38, n. 4, p. 724-729. Elsevier BV.
Palmer-Kazen U, Religa P, Wahlberg E. Exercise in Patients with Intermittent Claudication Elicits Signs of Inflammation and Angiogenesis. European Journal Of Vascular And Endovascular Surgery, 2009; 38(6):689-96.
Parmenter BJ, Dieberg G, Smart NA. Exercise Training for Management of Peripheral Arterial Disease: a systematic review and meta-analysis. Sports Medicine, 2014, v. 45, n. 2, p. 231-244. Springer Science and Business Media LLC.
B.V., A. M. S. OPortaMon™2011
Singh SJ, Morgan MD, Scott S, Walters D, Hardman A. Development of a shuttle walking test of disability in patients with chronic airways obstruction. Thorax, 1992, v. 47, n. 12, p. 1019-1024. BMJ.
Novakovic M, Jug B, Lenasi H. Clinical impact of exercise in patients with peripheral arterial disease. Vascular, 2016, v. 25, n. 4, p. 412-422. SAGE Publications.
Barbosa JPAS, Henriques PM, Barros MVG, Wolosker N, Ritti-Dias RM. Nível de atividade física em indivíduos com doença arterial periférica: uma revisão sistemática. Jornal Vascular Brasileiro, 2012, v. 11, n. 1, p. 22-28. FapUNIFESP (SciELO).
Malagoni AM, Felisatti M, Mandini S, Mascoli F, Manfredini R, Basaglia N, Zamboni P, Manfredini F. Resting Muscle Oxygen Consumption by Near-Infrared Spectroscopy in Peripheral Arterial Disease: a parameter to be considered in a clinical setting?. Angiology, 2010, v. 61, n. 6, p. 530-536. SAGE Publications.
Pedersen BL, Baekgaard N, Quistorff B. Muscle Mitochondrial Function in Patients with Type 2 Diabetes Mellitus and Peripheral Arterial Disease: implications in vascular surgery. European Journal Of Vascular And Endovascular Surgery, 2009, v. 38, n. 3, p. 356-364. Elsevier BV.
Manfredini F, Malagoni AM, Mandini S, Felisatti M, Mascoli F, Basaglia N, et al. Near-Infrared Spectroscopy Assessment Following Exercise Training in Patients With Intermittent Claudication and in Untrained Healthy Participants. Vascular And Endovascular Surgery, 2012, v. 46, n. 4, p. 315-324. SAGE Publications.
Hamburg NM, Balady GJ. Exercise Rehabilitation in Peripheral Artery Disease. Circulation, 2011, v. 123, n. 1, p. 87-97. Ovid Technologies (Wolters Kluwer Health).
Stewart KJ, Hiatt WR, Regensteiner, JG, Hirsch AT. Exercise Training for Claudication. New England Journal Of Medicine, 2002, v. 347, n. 24, p. 1941-1951. Massachusetts Medical Society.
