EFFECT OF ALBUMIN SUPPLEMENTATION ON OXIDATIVE STRESS MARKERS IN NUTRITIONALLY RISK KIDNEY PATIENTS SUBMITTED TO HEMODIALYSIS

Abstract

Chronic kidney disease involves metabolic and inflammatory complications that lead to important nutritional disorders, as well as an imbalance in the antioxidant defense. The study evaluated the effect of a dietary intervention on oxidative stress markers in renal patients undergoing hemodialysis. Intervention study, controlled clinical trial type, involving 43 individuals aged between 18 and 59 years of both sexes, on regular hemodialysis. The sample was divided into two groups: G1, with 15 patients at nutritional risk (serum albumin ≤ 3.5 g/dl); and non-supplemented group (G2), with 28 patients (albumin > 3.5 g/dl). In the 90-day follow-up period, each participant in G1 received 10 g of albumin supplement three times a week. Serum albumin, total cholesterol, HDL cholesterol (HDL-c) and triglyceride levels were obtained from clinic data. Antioxidant activity was evaluated by measuring plasma nitrite and erythrocyte superoxide dismutase enzyme activity; and lipid peroxidation through the concentration of malondialdehyde in plasma. A high proportion of patients had a dyslipidemic profile evidenced by reduced levels of HDL-C and increased levels of triglycerides. In addition to producing an increase in albuminemia, the supplementation resulted in increased antioxidant activity without altering lipid peroxidation.