FATORES DE RISCO E AVALIAÇÃO DO CRESCIMENTO DE CRIANÇAS COM DOENÇA METABÓLICA ÓSSEA DA PREMATURIDADE

Abstract

Objectives: To analyze risk factors for the development of Metabolic Bone Disease of Prematurity (MBDP) and to compare the growth of newborns (NBs) with MBDP with those without disease. Method: Longitudinal, observational and prospective study involving 54 NBs weighing less than 1500g or with gestational age (GA) <33 weeks, from the ICU, with follow up to eight months corrected. DMOPT was defined as an alkaline phosphatase (AF) dosage > 800U / L and / or serum phosphorus <5.6, mg / dl. Pre and postnatal risk factors for the development of MBDP and anthropometric measures were evaluated. The statistical analysis involved the t-student, Mann-Whitney, Levene, Chi-square and Fisher's exact tests. The level of significance was 5% in the analyzes. Results: The prevalence of MBDP was 59.3%. The GA and birth weight were lower among patients diagnosed with MBDP (29.5 ± 2.4 weeks / 1,219 ± 321g). There was a statistically significant association between the diagnosis of MBDP and late sepsis, p = 0.004, and DMOPT and Bronchopulmonary Dysplasia, p = 0.010. During anthropometric analysis, there was no significant difference. Conclusions: NBs who developed MBDP had lower GA and birth weight, but there was no impairment in the anthropometric assessment of their growth up to eight months corrected, in the comparison between the two groups.