EVALUATION OF ANTIMICROBIAL ACTIVITY OF THE FIXED OIL OF Bowdichia virgilioides KUNTH (FABACEAE) SEEDS
Palavras-chave:Medicinal plants, Sucupira-preta, Modulation,
ResumoBacterial resistance to current drugs is a major public health problem worldwide. The search for biologically active compounds that act synergistically with antibiotics for their use at lower concentrations would be of great help in overcoming bacterial resistance. Bowdichia virgilioides Kunth, also known as sucupira-preta or sucupira-do-cerrado, is a species of the family Leguminosae-Papilionoidea that occurs in both primary and secondary formations, always in fast-draining areas. The objective of this study was to evaluate of antibiotic modulation through of the fixed oil from the seeds of B. virgiloides activity. . The seeds showed a considerable amount of oil, with a yield of approximately 11%. The oil did not inhibit bacterial growth, but its combination with the antibiotics tested produced growth inhibition. Our data indicated that the oil extracted from B. virgiloides seeds has no antibacterial activity at clinically relevant concentrations, but when combined with aminoglycoside antibiotics, it showed modulatory activity, lowering the antibiotic resistance of Gram-negative strains.
Agra IK, Pires LL, Carvalho PS, Silva-Filho EA, Smaniotto S and Barreto E. 2013. Evaluation of wound healing and antimicrobial properties of aqueous extract from Bowdichia virgilioides stem barks in mice. Anais da Academia Brasileira de Ciências, 85(3):945-954.
Almeida JRGS, Silva-Filho RN, Nunes XP, Dias CS, Pereira FO, and Lima EO. 2006. Antimicrobial activity of the essential oil of Bowdichia virgilioides Kunt. Brazilian Journal Pharmacognosy, 16:638–641.
Barbosa-Filho JM, Medeiros KCP, Diniz MFFM, Batista LM, Athayde-Filho PF, Silva MS, Cunha EVL, Almeida JRGS and Quintans-Júnior LJ. 2006. Natural products inhibitors of the enzyme acetylcholinesterase. Revista Brasileira de Farmacognosia, 16(2):258–285.
Barbosa-Filho JM, Vasconcelos THC, Alencar AA, Batista LM, Oliveira RAG, Guedes DN, Falcão HS, Moura MD, Diniz MFFM & Modesto-Filho J. 2005. Plants and their active constituents from South, Central, and North America with hypoglycemic activity. Revista Brasileira de Farmacognosia, 15(4):392–413.
Benoit-Vical F, Grellier P, Abdoulaye A, Moussa I, Ousmane A and Berry A. 2006. In vitro and in vivo antiplasmodial activity of Momordica balsamina alone or in a traditional mixture. Chemotherapy, 52(6):288-292.
Borges KB. 2008. Revista Eletrônica de Farmácia, 5(2):12-20.
Cabral ME, Dias DDEQ, Sales DL, Oliveira OP, Teles DA, Filho JA, Sousa JG, Coutinho HD, Costa JG, Kerntopf, MR, Alves RR and Almeida WO. 2013. Evaluations of the antimicrobial activities and chemical compositions of body fat from the amphibians Leptodactylus macrosternum Miranda-Ribeiro (1926) and Leptodactylus vastus Adolf Lutz (1930) in Northeastern Brazil. Evidence-Based Complementary and Alternative Medicine, 2013:7.
Coutinho HDM, Costa JGM, Lima EO, Falção-Silva VS and Siqueira, JRJP. 2008a. Enhancement of the antibiotic activity against a multiresistant Escherichia coli by Mentha arvensis L. and chlorpromazine. Chemotherapy, 54(4):328–330.
Coutinho HDM, Costa JGM, Lima EO, Falção-Silva VS and Siqueira JRJP. 2009a. Herbal therapy associated with antibiotic therapy: potentiation of the antibiotic activity against methicillin – resistant Staphylococcus aureus by Turnera ulmifolia L. BMC Complementary and Alternative Medicine. 9(1):1.
Coutinho HDM, Costa JGM, Siqueira JRJP and Lima EO. 2009b. Effect of Momordica charantia L. in the resistance to aminoglycosides in ethicilin-resistant Staphylococcus aureus. Comparative immunology, microbiology and infectious diseases, 33(6):467-471.
Coutinho HDM, Costa JGM, Siqueira JRJP and Lima EO. 2008b. In vitro anti- staphylococcal activity of Hyptis martiusii Benth against methicillin-resistant Staphylococcus aureus-MRSA strains. Revista Brasileira de Farmacognosia, 18(Supl.):670-675.
Coutinho HDM. 2008. Avaliação da atividade antibacteriana e fotossensibilizante de produtos naturais da Região do Cariri Cearense. Tese de doutorado, Programa de pós-graduação em Farmacologia, Universidade Federal da Paraíba – UFPB, João Pessoa. 113p.
Deharo E, Bourdy G, Quenevo C, Munoz V, Ruiz G and Sauvain M. 2001. A search for natural bioactive compounds in Bolivia through a multidisciplinary approach. Part V. Evaluation of the antimalarial activity of plants used by the Tacana Indians. Journal of Ethnopharmacology, 77(1):91–98.
Dilika F, Bremner PD and Meyer JJ. 2000. Antibacterial activity of linoleic and oleic acids isolated from Helichrysum pedunculatum: a plant used during circumcision rites. Fitoterapia, 71(4):450-452.
Ferreira FS, Brito SV, Costa JG, Alves RR, Coutinho HD and Almeida WO. 2009. Is the body fat of the lizard Tupinambis merianae effective against bacterial infections?. Journal of Ethnopharmacology, 126(2):233-237.
Gibbons S. 2004. Anti-staphylococcal plant natural products. Natural Product Reports, 21(2):263-277.
Gunics G, Farkas S, Motohashi N, Shah A, Harsukh G, Kawase M and Molnár J. 2006. Interaction between 3,5-diacetyl-1,4-dihydropyridines and ampicillin, and erythromycin on different E. coli strains. In Vivo, 20(3):367-372.
Lambert RJW, Skandamis PN, Coote PJ and Nychas GJE. 2001. A study of the minimum inhibitory concentration and mode of action of oregano essential oil, thymol and carvacrol. Journal of Applied Microbiology, 91(3):453-462.
Lorenzi H. 1998. Árvores brasileiras: Manual de identificação e cultivo de plantas arbóreas nativas do Brasil. Plantarum, São Paulo, 352 p.
Lu Y, Zhao YP, Wang ZC, Chen SY and Fu CX. 2007. Composition and antimicrobial activity of the essential oil of Actinidia macrosperma from China. Natural Product Reports, 21(3):227-233.
Mbwambo ZH, Moshi MJ, Masimba PJ, Kapingu MC and Nondo RS. 2007. Antimicrobial activity and brine shrimp toxicity of extracts of Terminalia brownie roots and stem. BMC Complementary and Alternative Medicine, 7(1):7-9.
Molnar J, Molnar A, Spengler G and Mandi Y. 2004. Infectious plasmid resistance and efflux pump mediated resistance. Acta Microbiologica et Immunologica Hungarica, 51(3):333-349.
Moreno HPR, Costa-Issa FI, Rajca-Ferreira AK, Pereira MA and Kaneko TM. 2013. Native Brazilian plants against nosocomial infections: a critical review on their potential and the antimicrobial methodology. Current Topics in Medicinal Chemistry. 13(24):3040-3078.
Nicolson K, Evans G and O´Toole PW. 1999. Potentiation of methicillin activity against methicillin-resistant Staphylococcus aureus by diterpenes. FEMS Microbiology Letters, 179(2):233–239.
Saraiva RA, Araruna MK, Oliveira RC, Menezes KD, Leite GO, Kerntopf MR, Costa JG, Rocha JB, Tomé AR, Campos AR and Menezes IR. 2011a. Topical anti-inflammatory effect of Caryocar coriaceum Wittm. (Caryocaraceae) fruit pulp fixed oil on mice ear edema induced by different irritant agents. Journal of Ethnopharmacology, 136(3):504-510.
Saraiva RA, Matias, EFF, Coutinho HDM, Costa JGM, Souza HHF, Fernandes CN, Rocha JBT and Menezes IRA. 2011b. Synergistic action between Caryocar coriaceum Wittm fixed oil with aminoglycosides in vitro. European Journal of Lipid Science and Technology, 113(8):967-972.
Senatore F, Rigano D, Formisano C, Grassia A, Basile A and Sorbo S. 2007. Phytogrowth-inhibitory and antibacterial activity of Verbascum sinuatum. Fitoterapia, 78(3):244-247.
Singh G, Maurya S, Delampasona MP and Catalan CA. 2007. A comparison of chemical, antioxidant and antimicrobial studies of cinnamon leaf and bark volatile oils, oleoresins and their constituents. Food and Chemical Toxicology, 45(9):1650-1661.
Thomazzi CB, Silva DCR, Silveira CLC, Vasconcellos AF, Lira EVF, Cambui CS, Estevam AR and Antoniolli. 2010. Antinociceptive and anti-inflammatory activities of Bowdichia virgilioides (sucupira). Journal of Ethnopharmacology, 127(2):451-456.
Wagner H and Wisenauer M. 2006. Fitoterapia: fitofármacos, farmacologia e aplicações clínicas. São Paulo, Pharmabooks, 265 p.